![]() ![]() Unsupervised hierarchical clustering revealed three clusters, which were prognostic. There was, however, a significant difference in both ploidy and copy-number signature exposure between early-stage and late-stage samples, with higher ploidy and signature 4 exposure in late-stage cases. We found no significant differences in somatic mutations or focal copy-number alterations between early-stage and late-stage cohorts. To determine whether early-stage ovarian high-grade serous carcinoma (HGSC) represents a distinct genomic entity, we collected samples from 43 patients with stage IA–IIA HGSC to identify potential differences in short genomic variants and copy-number aberrations, and compared them with a cohort of 52 late-stage (stage IIIC–IV) cases.
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